Actinic cheilitis is a subtype of actinic keratosis that mainly affects the lower lip and has an increased risk of carcinomatous transformation. The location in the labial mucosa conditions the different therapeutic possibilities. Bermellectomy requires local or general anesthesia and is associated with a risk of unsightly scarring; treatment with 5-fluorouracil or imiquimod lasts for several weeks and the inflammatory reaction can be very intense. Several authors have used photodynamic therapy as an alternative to the usual treatments. We present three patients with histologically confirmed actinic cheilitis who were treated with photodynamic therapy using methylaminolevulinic acid as a photosensitizer and red light of 630 nm. The clinical response was good, with no recurrence after 3 to 6 months of follow-up. Our experience supports the use of photodynamic therapy as a good therapeutic alternative for actinic cheilitis.
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